Beilstein J. Org. Chem.2022,18, 1009–1016, doi:10.3762/bjoc.18.101
daturamycins was identified through gene knockout and biochemical characterization experiments and the biosynthetic pathway of daturamycins was proposed.
Keywords: biosynthesis; diarylcyclopentenone; polyporicacidsynthetase; p-terphenyl; Streptomyces; Introduction
Natural products containing a terphenyl
biochemical characterization indicated that the DatA is a polyporicacidsynthetase, which helped to propose a possible biosynthetic pathway for daturamycins in S. sp. KIB-H1544 (Figure 3B). Finally, the discovery of daturamycins, identification, and characterization of dat biosynthetic gene cluster allowed
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Graphical Abstract
Figure 1:
Structures of compounds 1–6, atromentin, and echoside C.